Anticonvulsant effects of desvenlafaxine on modulating brain monoamine and oxidative stress in mice

Abstract Desvenlafaxine succinate (DVS) inhibits serotonin reuptake selectively and is approved for major depressive disorders. This research investigated influence of DVS on modulating brain monoamine oxidative stress in mice. The antiepileptic potential (10, 20, or 30 mg/kg/i.p.) pentylenetetrazole (PTZ; 85 mg/kg) with i.p. route administration, strychnine (STR; 75 route, pilocarpine (400 s.c. maximal electroshock MES-induced convulsion mouse models. activities stress, i.e. superoxide dismutase (SOD), glutathione (GSH) lipid peroxidation (LPO) as well gamma-aminobutyric acid (GABA) the brains PTZ-induced convulsive Treatment increased latency to develop siezures declined mortalities rodents against PTZ, STR pilocarpine-induced convulsions. Results MES-leaded revealed that reduced tonic hind limb extension duration significantly. Brain, SOD, GSH GABA level were significantly (P<0.01) LPO after treatment. Furthermore, did not show any motor coordination signs rotarod test. We demonstrated role genesis mice under control condition attenuate damage.